The death of a loved one.
A divorce, separation, or breakup of a relationship.
Losing custody of children, or feeling that a child custody decision is not fair.
A serious loss, such as a loss of a job, house, or money.
A serious illness.
A terminal illness.
A serious accident.
Chronic physical pain.
Intense emotional pain.
Loss of hope.
Being victimized (domestic violence, rape, assault, etc).
A loved one being victimized (child murder, child molestation, kidnapping, murder, rape, assault, etc.).
Unresolved abuse (of any kind) from the past.
Feeling "trapped" in a situation perceived as negative.
Feeling that things will never "get better."
Serious legal problems, such as criminal prosecution or incarceration.
Feeling "taken advantage of."
Inability to deal with a perceived "humiliating" situation.
Inability to deal with a perceived "failure."
A feeling of not being accepted by family, friends, or society.
A horrible disappointment.
Feeling like one has not lived up to his or her high expectations or those of another.
Bullying. (Adults, as well as children, can be bullied.)